We thus wished to utilise data from this registry to address the question of whether treatment with etanercept plus MTX was more efficacious in clinical practice than treatment with etanercept alone.
Therefore, further research should be undertaken in order to gain more insight into the disease molecular mechanisms underlying the biology of BC which may aid in the administration of more efficacious treatments in clinical practice.
In view of the unmet clinical need for more efficacious haemostatic agents in such patients, clinical studies are now justified to confirm the observed favourable effects of PCC in the present preclinical model system.
Belshe et al. (29) reported that LAIV was 50% more efficacious than TIV against clinical infection in young children.
Further, dyadic family (37– 39) education sessions were briefer, standardized, and administered by less specialized facilitators; hence, they likely would be more cost-effective as well as more efficacious than coping instruction in a clinical setting.
Importantly, the control was FFP in three of the studies, thus providing some evidence that fibrinogen concentrate is more efficacious than FFP across a range of clinical outcomes in the perioperative setting.
This result met what we found in the clinical trial whereby acupoints were more efficacious than non-acupoints at managing migraine.
Taken together, these results suggest that in clinical practice, rituximab may be more efficacious than a subsequent anti-TNF agent in patients with moderately active to severely active RA and prior exposure to anti-TNF agents.
The presence of this protein appears to be an important prognostic factor and, combined with an age-adjusted International Prognostic Index, could allow researchers to design more specific clinical trials aimed at finding new, more efficacious and less toxic treatments.
While the current clinical data suggest bisphosphonates may be more efficacious in post-menopausal or oestrogen depleted patients, or those with hormone receptor positive tumours, to date no appropriately designed preclinical studies have evaluated these effects.
