The main objective for pharmaceutical industry is to provide more specific and more efficacious drugs by targeted treatment, i.e. by Personalized Medicine (PM), and to provide the diagnostic test that will direct the right patient group to the right drug.
PET can thereby potentially provide important benefits to the individual patient by allowing an earlier change to alternative treatments that may be more efficacious or by avoiding the unnecessary toxicity related to ineffective therapy.
A vaccine inducing partial pre-erythrocytic protection, like RTS,S/AS, might allow the development of a better and more sustained asexual-stage protection than a more efficacious vaccine, by allowing this "leakage" of low-dose parasites.
Instead, he cites Galen and Avicenna to show that women as well as men contribute material that forms the fetus; the female contribution, according to Agrippa, is the more efficacious, as shown by the strong resemblance of many sons to their mother.
Certain drug classes may be more efficacious than others by virtue of greater sigmoidicity of the concentration-response curve--with some protease inhibitors alone exhibiting greater than nine logs suppression of viral replication [ 5] in CD4+ T cells.
BUGESERA, Rwanda, 13 May 2011 – UNICEF welcomed the announcement yesterday of a national campaign to eliminate the vertical transmission of HIV from mother to child in Rwanda and confirmed its commitment to support the government in ensuring that all women in need will be reached with a new, more efficacious HIV regimen by 2015.
The results showed that AB, PRP and corticosteroids were more efficacious than placebo [estimated by standardized mean difference (SMD ]; however, there were no reports comparing the efficacy of PRP versus AB, PRP versus corticosteroids and AB versus corticosteroids.
However, except for melanoma, the use of IFN in most of these diseases has been replaced by more efficacious treatments that were gradually identified over a period of time.
More efficacious therapeutics may be obtained by selectively inhibiting the silencing pathway initiated by the relevant oncoprotein.
