This combined with our reported observations suggest the FAM33A_1 siRNA is a more efficacious agent with a reduced off-target potential relative to the FAM33A_2 siRNA and would be the siRNA of choice for any future applications.
Among subjects with LDL-C at their minimal acceptable goal, an elevated LDL-P would confer risk that may be reduced by adjustment of the statin dosage, change in statin from a less efficacious to more efficacious agent, or the addition of a further LDL-P lowering agent.
Perhaps, treating schizophrenia more aggressively with more efficacious agents [ 39] or combination therapy [ 40] could result in more patients reaching remission and reduce the economic burden on the healthcare system, but more research is clearly needed.
As these more efficacious agents allow patients to survive longer and to receive more lines of therapy, issues have arisen concerning the choice of the best schedule and the best sequence of treatments.
There is, therefore, a need for new and more efficacious agents, targeted not only at treatment, but also at prevention of the disease, its progression, and its associated complications.
Together, we have defined the underlying mechanisms of OXPHOS-dependent apoptotic pathway utilized by multiple anticancer agents, which may be exploited for future anticancer strategies or development of more efficacious anticancer agents.
In view of the unmet clinical need for more efficacious haemostatic agents in such patients, clinical studies are now justified to confirm the observed favourable effects of PCC in the present preclinical model system.
Dual immunotherapy via B cell depletion and BAFF blockade is more efficacious than single agent immunotherapy in murine SLE models, and this combination treatment is predicted to be an effective strategy for immunotherapy in human SLE.
Based on observations in other systems that combination treatment with ERK or JNK inhibitors restores chemosensitivity, we hypothesized that treatment with ATO and the multikinase inhibitor, sorafenib, would be more efficacious than either agent alone.
This hypothesis was supported by the observation that a combination of 2DG and the anthracycline, adriamycin, was significantly more efficacious than either agent alone in an osteosarcoma xenograft model.
In an in vivo model of BRAF/NRAS-wild-type melanoma, the co-targeting of MEK with an antibody drug conjugate targeted against EDNRB was more efficacious than either agent alone and was associated with good levels of tumour suppression (Asundi et al, 2014).
