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These results suggest that the ortho-phenolic hydroxyl on ring A is important for producing terphenyls with more efficacious activity.
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Importantly, SC-1 and SC-43 showed more efficacious antitumor activity and p-STAT3 downregulation than sorafenib in MDA-MB-468 xenograft tumors.
Passive interventions are typically considered to be more efficacious than active interventions (Haddon Jr. 1980).
Results indicate the agent was accepted and liked, and was significantly more efficacious at increasing physical activity (daily steps walked) than the control.
Therefore, stimulating hERG1 channel activity could be preparatory for more efficacious effects of an activated immune system and/or antiproliferative drugs.
However, etanercept was more efficacious in the active comparator trial.
To test the hypothesis that a tailored workplace based intervention incorporating specific behavioural strategies for calcium intake and physical activity is more efficacious than standard care (simple print resource distribution) in increasing the calcium intake and physical activity levels.
The current study also confirms that multilevel, school-driven programs are more efficacious than individual or interpersonal physical activity interventions".
The newer antifungal agents, such as amphotericin B lipid formulations and the echinocandins, exhibit novel activity and may be more efficacious against Candida biofilms [ 17].
Further research is needed to identify correlates of physical activity in different subgroups to design more efficacious interventions.
Moreover, mindfulness practice, in particular, may be more efficacious in symptom relief than the well-being promoting activities cultivated in the HEP program.
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