Sentence examples for more efficacious action from inspiring English sources

These responses are consistent with a more efficacious action of the biased agonist.

Importantly, the maximum dilatation to MM07 was approximately double that seen with [Pyr]apelin-13, consistent with a more efficacious action of the biased agonist.

Likewise, studies on steroidal estrogens used in hormone replacement have shown that some B-ring unsaturated compounds have distinct tissue-selective actions, being more efficacious in vasomotor, neuroendocrine and bone preservation parameters than in other peripheral actions of estrogens [ 28*].

In this chapter, we will cover some of these strategies for knowledge-based rational design for GPCRs and will discuss the main hurdles which they may need to overcome to yield novel, safer and more efficacious drugs possessing polished mechanisms of action.

Evidence indicates that concurrent use of a repertoire of different oncolytic viruses (with different modes of action) may produce more efficacious therapeutic response.

We hypothesize that for patients with severe hypotension, lower doses of multiple vasopressors with differing mechanisms of action may be more efficacious and less toxic than high doses of one type of vasopressor (that is, catecholamines).

Given these limitations of dopamine, there is an unmet need for compounds that lack hemodynamic action and yet are more efficacious than dopamine.

Valdecoxib is more efficacious and has a longer duration of action than other oral NSAIDs and coxibs; parecoxib brings the benefits of an injectable coxib drug to the peri-operative and immediate post-operative period as well as to patients who are unable to swallow or are nauseated and vomiting.

Therefore novel dopamine derivatives lacking any hemodynamic actions and yet are more efficacious in protecting tissue from cold preservation injury are warranted.

XEs are both imperfect potent estrogens and endocrine disruptors; the more efficacious an XE, the more it disrupts actions of physiologic estrogens.

The current study also confirms that multilevel, school-driven programs are more efficacious than individual or interpersonal physical activity interventions".