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Since the anti-DHAV mechanisms of 1 and 2 in vitro probably involve suppression of replication and release, 2's better performance in anti-DHAV may result from its far more effectively inhibiting virus replication.
It is likely, however, that new approaches for more effectively inhibiting osteoclast-mediated bone resorption will become available; for example, agents that specifically inhibit osteoclast formation or activity by targeting mediators such as RANKL.
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These analyses revealed that GSI XII has similar anti-Notch effects as DAPT or SAHM1, but even more effectively inhibits MM growth and induces apoptosis, possibly due to concomitant proteasome inhibition.
In contrast, CatS-inh more effectively inhibited the proliferative response compared with the effect of CatL-inh, indicating that cathepsin S, rather than cathepsin L, plays a crucial role in antigen processing and presentation of APCs.
Costa et al. [ 54] also reported that ranibizumab was moderately more effective at inhibiting endothelial cell proliferation than bevacizumab, while in an acute assay bevacizumab more effectively inhibited VEGF-stimulated VEGFR2 and MAPK phosphorylation in human microvascular endothelial cells.
Previous studies also showed that silver nanoparticles could more effectively inhibit E. coli than S. aureus (Kim et al. 2011).
Furthermore the EIS measurement suggested that the HA/GO coating more effectively inhibited the Mg substrate from corrosion compared to pure MAO coating.
In contrast, IDH more effectively inhibits electron transfer from the conduction band of TiO2 to the dye excited state, resulting in a higher open-circuit photovoltage (Voc).
Two novel antiplatelet agents, ticagrelor and prasugrel, have been shown to rapidly and more effectively inhibit the P2Y12 receptor compared with clopidogrel.
As shown in Figure 5, the results demonstrate that the combination of the PLA/Au nanocomposites with DNR could more effectively inhibit the growth of these two different kinds of leukemia cells than that treated with DNR alone.
The compact TiO2 hole-blocking layer more effectively inhibits the direct contact between the FTO and the perovskite (preventing the back electron transfer), which is predicted as the origin of charge recombination from the one-diode model.
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