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(2) Alternatively, IgG4 may aid in the clearance of immune complexes by forming larger complexes that are more effectively cleared.
Tissue damage was most prominent in young mice and in those strains of mice that more effectively cleared S. aureus, and was not significant in older mice and mouse strains that had a more limited immune response to the pathogen.
As expected, this mutant was also more susceptible to leukocyte-inflicted damage when grown on a three dimensional model of the human oral mucosa (Fig. 8C), supporting our hypothesis that it may be more effectively cleared in the oral environment.
These particles are in turn more effectively cleared from the circulation due to a relative decrease in apoC3.
Thus, products of innate responses to microbes that are more effectively cleared by IgG and TH1 inflammation might be expected to promote TH1-acquired responses.
Because phylloquinone is transported with the triacylglycerol-rich fraction and menaquinones are transported both by triacylglycerol-rich lipoprotein and LDL, phylloquinone is more effectively cleared from the circulation by the liver for activation of clotting factors than menaquinones (23).
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It is still possible that in smaller populations, stochastic effects such as Muller's ratchet may occur, and allow sex to more effectively clear detrimental mutations in the absence of beneficial mutations [ 27].
Still, drugging myself into oblivion didn't seem to offer concrete solutions; I realized I could fight for rave culture's ideals of openness and inclusivity more effectively clear-eyed and sober.
A study by Zeyl and Bell [ 33] with Saccharomyces cerevisiae populations suggested that sex served to more effectively clear detrimental mutations than accumulate beneficial ones.
8, 15, 16 Therefore, case management with artemisinin is expected to have a larger impact on P. falciparum transmission than P. vivax transmission because treatment may more effectively clear infection before patients are infectious.
While current dosing regimens in widespread use were effective for relatively sensitive parasites, the specter of artemisinin resistance raised the question of whether higher doses might more effectively clear resistant strains.
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