What we report in the manuscript is our observations that the "open" conformation of Dvl was more effective in triggering JNK activation.
BITC was also considerably more effective in triggering the activation of caspase-9 and -3, degradation of PARP, and release of cytochrome c.
Consistent with these findings, UA was considerably more effective in triggering activation of caspase-3, -8 and PARP degradation in ezrin knockdown cells, relative to vector control cells.
Chronic oral drug administration was slightly more effective at triggering TD in capuchins than depot i.m. preparations, with incidence of 53% and 42%, respectively, but the cumulative drug exposure resulting from these two drug regimens may well have differed.
Having demonstrated that certain Gβ1γx/PLCβ2/3 combinations were more effective in triggering PKD activity in HEK293 cells, we asked if similar Gβ1γx selectivity for PKD phosphorylation could be observed in HeLa cells that endogenously express high level of Gβγ-sensitive PLCβ3.
Recently, it has become apparent that highly purified HMGB1 has only minimal cytokine-like activity in vitro, whereas Escherichia coli-derived recombinant HMGB1, presumably contaminated with trace amounts of various microbial products, is more effective at triggering TNF secretion by cultured macrophages [ 80, 81].
Assuming that spikes in bipolar cells are more effective in triggering vesicle release compared to graded potentials, a design in which an RGC receives many spiking inputs from bipolar cells would have the potential advantage of making the spike train leaving the RGC less susceptible to noise within that one neuron.
Therefore, a more effective and controllable strategy to trigger the rupture of the RMP-based liquid marbles is practically desirable.
The results obtained indicate that α cells trigger a more effective antiviral response than β cells, including higher basal and induced expression of STAT1-regulated genes, and are thus able to better clear viral infections as compared to β cells.
It is noteworthy that the event trigger with combinational measurements avoids decoupling the actual state of the nodes, which is more effective than the error-based event trigger.
