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Knowledge of the mechanism by which arsenic trioxide exerts the anti-tumor effects may help in designing a more effective regimen for therapy.
That first exciting result compared Avastin with a type of chemotherapy that has since been widely replaced by a more effective regimen.
Therefore, a more effective regimen should be used to improve the survival of non-GCB subtype DLBCL patients.
The present study was designed to test whether the combination of cisplatin and irinotecan with ifosfamide can develop a more effective regimen.
Results from this trial indicated that the 150 mg/m qw 3/4 dose of nab-paclitaxel was a significantly more effective regimen than docetaxel [ 13].
This could spare patients toxicity of non-efficacious therapy, and allow revision to a potentially more effective regimen in patients who are destined to respond poorly to the initial treatment.
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Standard chemotherapy for poor-prognosis metastatic nonseminoma has remained bleomycin, etoposide, and cisplatin (BEP) for many years; more effective regimens are required.
More effective regimens had been eagerly awaited.
Given the limited benefit seen from standard chemotherapy in HR+ breast cancer, identifying less toxic, more effective regimens is of interest.
The identification of molecular predictors of patient outcomes will help us design safer and more effective regimens that are tailored to individual patients.
More effective regimens are needed and a better definition of at risk patients is required for planning meaningful randomized controlled studies in this field.
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