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Stage migration as an effect of more effective imaging procedures is likely to be partly responsible for this improved survival.
Whole IgG versions of radioligands tend to have protracted blood pool activity and reduced tissue penetration whereas the shorter circulatory half life and increased tissue penetration of antibody fragments may produce more effective imaging agents.
This means that an increasing proportion of patients is probably diagnosed with smaller and/or fewer metastatic lesions due to increasingly more effective imaging techniques.
A number of obstacles remain including regulatory issues, length of clinical trials, the lack of validation and consensus on new biological markers, and the fact that recent developments in more effective imaging technology are not yet commonly used.
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To take advantage of the superior resolution and the accurate uptake quantification offered by positron emission tomography (PET), several tracers have been proposed for a more effective functional imaging of NET.
This strongly supports the need for more effective preoperative imaging to improve staging in order to avoid futile surgery.
Another orange-emitting fluorescent protein, which has higher pH-resistance and is more effective for imaging, was discovered in Fungia concinn [ 25].
This machine provided more effective PET/CT imaging than the first generation PET scanner; we therefore stopped recruiting patients to the study after including the one hundred and thirtieth patient.
Similarly, contrast agents with small sizes were more effective in tumor imaging because of the enhanced permeability and retention effect.
To the extent that molecular imaging can be a more effective alternative to traditional anatomical imaging, such figures indicate a big market opportunity, says Hamill, who follows CTI Molecular Imaging.
In the coming year not only will a steady pace of innovation and discoveries be maintained, but the world will also begin to see the emergence of more effective therapeutic, diagnostic and imaging methods.
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