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This principle enabled Lavoisier to put what was essentially Aristotle's notion of simple substances (302a15ff., quoted in section 1.1) to much more effective experimental use.
Four of the company's immuno-oncology drug trials had to be stopped due to the ethical need to offer the more effective experimental treatment to the other arm of patients receiving standard care.
Thus, we suggest that modelling the disease using the strategy described in this report is a more effective experimental approach.
This could not be evaluated because there were no significant differences in the clinical effect between the arms in both Trial 1 and Trial 2. If newer, much more effective experimental treatment were presented in the trials, the outcome could be better in trial participants, which was the case in the adjuvant chemotherapy trial for osteosarcoma (Link et al, 1986).
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A comparison of the proposed scheme with the base-centric scheme shows that proposed scheme is up to 35% more effective in each experimental case.
Our results suggest that increased attention to trophic interactions, diversity measures other than richness, and particularly the effects of consumers on evenness and primary productivity, will improve our understanding of the relationship between diversity and ecosystem functioning and allow more effective links between experimental results and real-world changes in biodiversity.
Compared with orally induced tolerance, nasally induced tolerance has been shown to be equally or, in the case of a peptide antigen, even more effective in curbing experimental autoimmune diseases [ 8, 27].
Currently, more effective bioinformatic prediction and experimental validation has been used to improve the design of antibody affinity ligands.
Benefits include optimized study designs which result in the use of fewer experimental animals, more effective answers to the questions of interest and an increased probability of successful publication.
Whether more frequent intervals of spontaneous breathing might be more effective in this regard awaits experimental proof.
Moreover, in agreement with a possible role of mTORC2 in mediating central neuronal plasticity, the dual mTOR inhibitor Torin 1 appeared to be more effective than rapamycin in this experimental model, either after one injection or after repeated administrations [ 45].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com