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Nanotechnology contributes towards a more effective eradication of pathogens that have emerged in hospitals, veterinary clinics, and food processing plants and that are resistant to traditional drugs or disinfectants.
Therefore, these data suggest the potential clinical effectiveness of TAA-based immunotheraputic strategies, alone or combined with DNA hypomethylating drugs, for more effective eradication of MCSC and non-MCSC neoplastic cells in patients with cutaneous melanoma.
Furthermore, the accumulation of azithromycin in phagocytic cells is suggested to contribute to a more effective eradication of phagocytised bacterial organisms [ 30].
Such treatments may boost host immunity, thereby leading to more effective eradication of the primary infection, prevention of secondary infection, decreasing latent virus reactivation and, hopefully, improving outcome.
Furthermore, there is in vitro evidence of synergy between azithromycin and cephalosporin as well as more effective eradication for pharyngeal gonorrhea [ 46].
These findings are exciting and are consistent with previous mathematical model predictions that shortening the interval between chemotherapy cycles could result in more effective eradication of malignant cells, potentially improving survival.
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Two trials involving 81 pregnant women show treatment lasting 7 days was more effective (98% eradication) than treatment for 4 days (49% eradication, OR 0.09, 95% CI 0.03-0.24) [ 38, 39].
"Over the longer haul, we can expect to see more effective drug eradication and increased interdiction of illicit drug shipments," President Bill Clinton predicted in January 2000.
In addition, the time until next exacerbation was significantly greater with moxifloxacin than the comparator during 9-month follow-up [ 22], which may be attributed to more effective bacterial eradication by moxifloxacin [ 23].
Molecular methods that can detect the contaminants even at very low numbers at any given stage would help in the design of more cost effective eradication strategies and better targeted antimicrobial treatments.
Therefore, combination therapies that simultaneously attack both dormant hypoglycemic/hypoxic tumor cells and the proliferating tumor cells of solid tumors are likely to be more effective in tumor eradication than existing approaches.
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