C9-4 administered by i.p. injection reduced the volume of brain infarction significantly at doses of more than 3 mg/kg, and the dosage of 5 mg/kg or 10 mg/kg demonstrated the most potent effect and were more effective than equivalent doses of the other inhibitors such as MDL72527 and N-benzylhydroxylamine.
In comparison, composite metal oxide-loaded Al2O3 was more effective at equivalent loadings (about 4.2 wt%), suggesting synergistic effects.
Moreover, our findings suggest that intermittent oral administration is even more effective than equivalent IV dosage in regards to PTH suppressive effect.
Thus, NBQX treatment in the AIA model is more effective than equivalent administration of approved drugs.
In mice bearing 4T1 murine breast tumor allografts, the dendrimer conjugate, at a Dox concentration of 1 mg/kg, was more effective than the equivalent concentration of free Dox and tumor size reduction was equivalent to that seen using 4 mg/kg free Dox.
Our results demonstrated that thrice-weekly oral alfacalcidol administration is more effective than an equivalent thrice-weekly IV regimen.
Fourth, despite having eight additional mismatches to the target, wild-type repair templates were always more effective than their equivalent templates with I-SceI sites.
Characterization of the inhibitory activity of kringle (K) fragments of angiostatin demonstrated that K1, K2 and K3, but not K4, inhibited endothelial cell proliferation, whereas a structure combining K1 3 was more effective than K1 4 (equivalent to angiostatin) [ 25].
Previous research has revealed that tactile warning signals can sometimes be more effective than the equivalent auditory or visual warning signals (for a review, see Prewett et al., 2012; see also Deatherage, 1972; Fitch et al., 2007; Ho & Spence, 2008; Spence & Ho, 2008b).
