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Radiation biological considerations are based on the assumption that the α/β value for prostate cancer cells is 1.5 Gy, so that a biologically more effective dose could be administered due to hypofractionation without increasing risks of late effects of bladder (α/β = 4.0) and rectum (α/β = 3.9).
What he didn't say -- but what everyone understood -- is that using a higher, more effective dose of Claritin would affect how the drug was described on the label.
The administration of a therapeutically more effective dose of nal-IRI (i.e., 20 mg/kg), while safe and efficacious [35], would have reduced sensitivity in the measurement of FAZA uptake due to potential disappearance of tumor hypoxia following partial or complete response and could also have introduced measurement bias due to rapid tumor volume shrinkage.
Hereby, a biologically more effective dose distribution might be achieved while simultaneously sparing normal tissues.
Then we chose the highest, more effective dose (45 μg kg−1 s.c).
Therefore, we used the more effective dose, GJ 200 mg/kg, in subsequent experiments (Table 1 and Figures 1 and 2).
Similar(46)
The reason the dose was so low, he argued, is that evidence of sedation began to crop up at higher, more effective doses.
This loaves-and-fishes approach means that less is more: The same amount of viral material can be spread out into many more effective doses, reducing the need to ration vaccines in the event of a true pandemic.
Epilepsy researchers are consequently seeking new ways to deliver AEDs directly to the seizure focus in the brain in order to deliver higher, more effective doses to the seizure focus whilst bypassing the remainder of the brain and body to prevent side effects.
It seems also clear that LS102, the more specific HRD1 inhibitor (37), produced a more effective, dose-dependent recovery of sarcoglycans.
A better understanding of the relationship between insulin dose and hypoglycemia may facilitate more effective dosing, thus reducing the risk of hypoglycemia and hyperglycemia.
More suggestions(15)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com