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These subtle changes, however, are important to bring the catalytic components into more effective conformations.
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This makes the tree more effective at eliminating similar conformations at the expense of a greater number of RMSD calculations.
Thus, the inhibitor will be able to hold the M2 channel in the closed conformation with a more effective way, just like a hoop in fastening a barrel, as shown by Fig. 4B.
What we report in the manuscript is our observations that the "open" conformation of Dvl was more effective in triggering JNK activation.
For instance, Vivanco et al. [ 3] indicated that therapeutic failure may be in part explained by insufficient levels of EGFR inhibition, and that targeting its inactive conformation may be a more effective strategy.
Since antibodies specific to conformational epitopes presented in quaternary structures may be more effective at binding native M2 [ 8], a tetrameric conformation-stabilized recombinant M2e was predicted to be more immunogenic than other M2e forms.
Since antibodies specific to conformational epitopes presented in quaternary structures may be more effective at binding M2 on cell surfaces [ 8], a tetrameric conformation-stabilized recombinant M2e presented in a membrane-anchored form, such as those incorporated into VLPs, was predicted to be more immunogenic than other M2e forms.
Knowledge of the effect of void architecture on cell proliferation and conformation could lead to the development of more effective scaffolds for tissue engineering.
Strong preference of the O N1 CO unit for the antiperiplanar amide bond conformation seems to be the major limit for more effective zinc chelation.
Therefore, it is more effective to use computer-aided design methods to optimize structural features supporting the binding loop conformation to more closely replicate the native starting structure.
They're more effective".
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