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The superior performance of specialist centres may be down to several possible factors: more effective surgery to remove the tumour; doctors prepared to re-operate if necessary; use of more effective chemotherapy drugs; and many more chemotherapy cycles.
It has only become more difficult as newer and more effective chemotherapy drugs come with "exorbitant" prices, says Wendy Stock, professor of medicine and director of the leukemia program at the University of Chicago.
The advent of better imaging modalities, more effective chemotherapy, improved radiotherapy techniques, a better understanding of anatomy with continuous refinement in surgical techniques and advances in prosthesis design and materials have all played a part in increasing the incidence of limb salvage surgery.
Theranostic nanomedicines that integrate diagnostic and therapeutic functions within an all-in-one platform can increase tumor selectivity for more effective chemotherapy and aid in diagnosis and monitoring of therapeutic responses.
Newer and more effective chemotherapy regimens have been tested in the early disease setting.
17 18 Moreover, a switch to more effective chemotherapy regimens has occurred.
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Screening cancers for mutations in these genes could help customize more effective chemotherapies, allowing avoidance of TLD-inducing drugs in mutant tumors that are likely to be resistant.
Combining PARPi with chemotherapy was more effective than chemotherapy alone with increased tumour cell DNA damage and death, and intratumoural DAB4 binding.
Given the very limited trials to date it remains an unanswered question as to whether perioperative chemotherapy treatment is more effective than chemotherapy started only after the surgical wound has healed.
In HER2-overexpressing or -amplified (HER2-positive) breast cancer patients, large phase III trials demonstrated that trastuzumab in combination with chemotherapy was significantly more effective than chemotherapy alone both in advanced disease and in adjuvant setting (Slamon et al, 2001; Piccart-Gebhart et al, 2005; Romond et al, 2005; Robert et al, 2006; Slamon et al, 2011).
Cytotoxic assays showed that chemotherapy with siRNA targeting MKP-1 was significantly more effective than chemotherapy in the presence of MKP-1.
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