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Our dual-agent liposomal formulation caused, through a more effective activation of the 5-FU prodrug into active metabolites interfering with TS, an increase in the induction of both cell death and apoptosis.
Although both MW/H2O2 and MW/S2O2−8 yielded ⩾97% antibiotic degradation with 1.2 g H2O2 and 0.87 g S2O2−8 per gram total solids, respectively, at 160 °C in 15 min, MW/S2O2−8 was found to be more promising for efficient sludge treatment at a lower temperature and a lower oxidant dosage, as it allows more effective activation of persulfate to produce the SO−4 radical.
In this study, we showed that Elmo is increased in Dock3 Tg mice, suggesting more effective activation of Rac1 signaling in these mice.
Moreover, there is a possibility that the combination therapy of HVJ-E and other immune therapies, such as CTLA-4 antibody, exhibits a more effective activation of antitumor immunity, and it will be performed in the near future.
As ROS are a main cause of DNA damage (Kryston et al, 2011), their presence may also account for the increased DNA damage observed in tumour cells from co-treated cultures/animals, resulting in more effective activation of cell death pathways.
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That TL-12 lamps were more effective activators of NFAT in epidermal equivalents than Arimed B lamps, is consistent with data showing that TL-12 lamps are more effective at inducing NFAT transcriptional activation and nuclear translocation in cultured keratinocytes in vitro.
It is known, that for the formation of PDE bond in non-enzymatic reactions, activation of 3′ hydroxyl of nucleotide is significantly more effective than activation of its 5′hydroxyl [ 67, 68].
We also demonstrated that mRNA:pU activation of mouse and human dendritic cells was significantly more effective than activation using single stranded mRNA.
Proper mechanical stimulation can maximize muscle spindle solicitation, which may produce a more effective muscle activation.
EDC is more effective for activation of carboxyl groups; therefore, we added 50 μl EDC (0.1 M) to 200 μl Herceptin (2 mg/ml) solution in MES buffer.
This finding is consistent with an early report of more effective JNK activation in COS-7 cells expressing mutant Dvl lacking the PDZ domain than in cells expressing wild-type Dvl (Sokol et al., 1995; Axelrod et al., 1998; Li et al., 1999; Moriguchi et al., 1999; Yamanaka et al., 2002; Gao et al., 2010).
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more appropriate activation
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