Sentence examples for more durable responses from inspiring English sources

We hypothesized that combining targeted therapy with immunotherapy could result in more patients with responses and/or more durable responses.

However, these combinations do not appear to produce more durable responses than cytokines alone [ 19– 24].

Once again, the benefits were relatively modest in terms of prolongation of median overall survival, but a minority of patients achieved what appeared to be more durable responses.

In relapsed and refractory CLL, the combination of rituximab and lenalidomide leads to higher and more durable responses than lenalidomide alone, although a randomized comparison has not been reported.

The strong rationale in combining anti-ERBB2 agents with PI3K/AKT inhibitors, together with the identification of genomic alterations conferring sensitivity to targeted inhibition, are guiding the design of clinical studies aimed at preventing the emergence of drug resistance and achieving more durable response.

A more recent randomised placebo controlled study using rituximab in the second-line setting demonstrated a much less favourable response, and although those who achieved CR on rituximab had a more durable response the benefits were small [ 31].

These data indicate that, compared to BPC chemotherapy responders, the NovoTTF-100A responders may have had a longer time to response after treatment initiation and, when responded, they had a more durable response.

Based on this mechanism of action and on our experience with this patient, PSA flare may correspond to a high degree of tumor cell kill and may be associated with more complete and more durable response to radium-223.

Therapies that specifically target these cells, which are believed to be pivotal for the growth and maintenance of the entire tumor mass, may result in a more durable response and even in a cure for the disease.

Interestingly, there were suggestions of greater ACR and EULAR responses, and greater LDAS and DAS28 (erythrocyte sedimentation rate) remission rates in the abatacept group than in the infliximab group, and a more durable response in the abatacept group, although it should be noted that in the infliximab group only the 3 mg/kg dose was used (with no opportunity to dose escalate).

Although bevacizumab clearly reduces the early perilesion edema associated with radiosurgical treatment of recurrent malignant gliomas and produces radiologic responses by RANO criteria, it remains unproven whether the combination of radiosurgery and Avastin produces a more durable response, as measured by OS, than radiosurgery or bevacizumab alone.