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This situation is likely to be due to transient dysregulation of the regenerating B-cell compartment during recovery post transplantation, which has been associated with a good prognosis and reveals a more durable immune reconstitution.
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Recent studies highlight the crucial role of proliferating, activated effector memory Th1 CD4+ T cells in effective antitumor immunity and reveal that CD4+ T cells induce more durable immune-mediated tumor control than CD8+ T cells.
A trend to more durable cellular immune responses in T5 was observed at 1 year (T5 vs T4/D; P =.07).
The immune contexture of SFT patients is heavily involved in anti-angiogenic therapy and it could be exploited to achieve more durable disease control through immune-based combination strategies.
Use of sipuleucel-T earlier in the prostate cancer paradigm may have considerable benefits to patients, since these patients are generally able to mount more robust immune responses [ 15, 22, 27], and there may be more time for the sustained, durable immune responses to exert their clinical benefit [ 32– 32].
Heavier paper is more durable and more resistant to wrinkling.
Infants respond best to PS protein conjugate vaccines because the immune response is more durable.
Every time Silicon Valley recovers from failure, it seems to grow more durable, almost in the same way a person becomes "immune" to a disease after a brush with it.
The reason for this is currently unknown, but could possibly be related to the existence of a robust and long-lasting immune response to PH20 in individuals with pre-existing antibodies which predisposed towards more durable boosting.
Altogether, these findings pave the way for the design of therapies that combine immune-based approach with anti-angiogenic treatment in SFT patients to achieve a more durable control of this aggressive disease.
Or more durable.
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CEO of Professional Science Editing for Scientists @ prosciediting.com