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States may choose one or more drug classes and must develop or review and update their care plan to reduce utilization and remediate any preventable episodes of care where possible.
Furthermore, nearly two-thirds (65.9%) of Canadian patients aged 65 years and over had claims for 5 or more drug classes, and more than one-quarter (27.2%) of seniors had claims for 10 or more drug classes.
All raltegravir patients had primary resistance mutations against 1 or more drug classes, 32 (100%) had primary resistance mutations against 2 or more drug classes and 26 (81.3%) had primary resistance mutations against 3 classes.
Because the study subjects frequently used medications in two or more drug classes, we included fill rates for all seven drug classes in each equation.
Safe and effective combination of two or more drug classes is recommended for the majority of patients with hypertension to achieve their BP goal, which may translate into reduced risk of CV outcomes [ 8– 14].
The remaining 37%% of patients either switched drug classes during this period or received a regimen consisting of three or more drug classes, predominantly nucleosides, NNRTIs and boosted PIs.
Similar(53)
In this study, we found that over 95% of Shigella isolates from the Monterey region of California were resistant to three or more antimicrobial drug classes, and 38% were resistant to five or more.
ACE-inhibitors and other more recent drug classes are not included in the analysis because they are too expensive for widespread use in Africa and would most likely be dominated within our analytical framework.
On the other hand, we found that introducing more drug-target classes may not always lead to better prediction accuracy.
SBP also declined 9.1 mm Hg less by 24 months for patients taking four or more blood pressure drug classes at baseline vs one drug class.
More than two drug classes were used in 23.5% of patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com