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This may be owing to the more drastic alteration of structures surrounding L265 expected from the insertion of three irrelevant amino acids in L265RPP as compared with the single amino-acid substitution in L265P, which may also explain the difference in degradation through the ubiquitin-proteasome pathway.
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He had made six changes and suggested further, more drastic alterations will follow when he can start trading.
Shifting visitation patterns under climate and environmental change may have more drastic alterations to the economic well-being of the region under a longer planning horizon.
Furthermore, inhibition of Rac-1 activity occurred over an extended time and thus differed from rapid and more drastic alterations studied in other model systems.
Yeasts of the acapsular mutant (Cap 67) presented more drastic alterations when grown in the presence of 1 μg/ml (Figs. 3B-D) or 2.5 μg/ml (Figs. 3E-F) of subfraction F2.4.
But we need far more drastic change.
Yeasts treated with 2.5 μg/ml of subfraction F2.4 showed more-drastic alterations with irregular buds emerging from the lateral of the mother cells instead of from the usual terminal, complete loss of the normal cellular ovular shape, cell wall detachment (arrows), membranous structures (arrowheads) and extracted cytoplasm suggesting cell death (Figs. 2E-F).
When months pass like that, as we all know they sometimes do, measures more drastic than alterations in facial hair may need to be taken to keep the passage of time from becoming too oppressive.
Interestingly, yeasts of the acapsular mutant C. neoformans Cap 67 showed more drastic ultrastructural alterations than the other strains.
But he's silent about a more voluntary, if no less drastic, alteration: the shearing away of the Kerr character's 8-year-old son in favor of a lurid backstory of sterility brought on by her husband's infidelity.
The heating phase beyond the critical temperature may become more viscous which indicates a rather drastic alteration of the nanofluid rheological properties leading to hysteresis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com