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It was shown earlier that a larger and more diverse reference set can improve the imputation of low-frequency variants.
We expect that a more diverse reference panel will help to resolve this issue in the future.
The resulting clades can be approximated by the tree-building algorithm, and this tree can help in selecting a more diverse reference panel.
As sequencing projects produce larger and more diverse reference datasets, imputation-based GWAS will also face practical challenges like choosing appropriate reference panels and keeping computation tractable.
This "best match" strategy produced useful results in several studies, but it can yield suboptimal accuracy with more diverse reference collections (The International HapMap Consortium 2010) or in studies with no clear reference matches (Huang et al. 2009a).
These panel selection strategies become harder to apply and interpret as sequencing efforts like the 1000 Genomes Project produce larger and more diverse reference sets, which led us to develop an alternative framework.
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Experts generate more unique scenarios and include more diverse referenced articles than did non-experts [51].
We are becoming more diverse with reference to ethnicity, race, gender, and sexual orientation.The old binaries are breaking down.
Different from most existing results with a single linear time-invariant (LTI) leader dynamics, the leader dynamics under consideration is composed by a family of LTI models and a switching logic governing the switches among them, which is capable of generating more diverse and sophisticated reference signals to accommodate more complicated consensus control design tasks.
This observation agrees with other publications, which state that a more diverse set of reference haplotypes increases the accuracy in imputation [27].
This strategy has been justified: the MAGIC population is more diverse than the UK reference Avalon × Cadenza population but less diverse than the panel of 64 varieties used here for comparison.
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more diverse materials
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