Experiments with a larger and more diverse cancer cell line panel may eventually reveal additional correlations between cancer cell tissue of origin or molecular subtype and growth response in co-culture.
Thus, while there is evidence for a larger and more diverse T cell infiltrate in tumor compared to control tissues (P < 2.2 × 10−16, chi-squared test), these results suggest that a large proportion of tumor-associated T cells are bystanders, not readily distinguishable from the normal population of tissue resident T cells.
We learned so much about how proteins misfold, how they are mis-directed and how clearance properties are altered, and these fundamental ideas have helped us to understand the much more complex, diverse cell populations in humans.
Heterozygosity at MHC loci may therefore enhance resistance to infectious diseases by binding and presenting a wider range of antigens to T-cells on the one hand [ 1], while on the other, generating a more diverse T-cell receptor repertoire during T-cell maturation [ 2- 4].
The expansion of β subcluster genes in reptiles and mammals might have given rise to a higher molecular repertoire to mediate a more diverse and/or complex cell-cell interaction network.
These results showed that more biologically diverse cells can sense and respond to differences in ECM patterns, and therefore suggested that ECM presentation may impact many types of cellular behaviors in complex cells such as stem cells, cancer cells, etc.
Therefore, larger amount of transcript sequences and more diverse tissues or cell types could enhance the AS information.
Thus, it is possible that the differential expression of other miRNAs not previously identified, specifically those involved in the regulation of Ig production, may be detected in a more diverse WM tumor cell population.
We have shown that even with this limitation we can achieve a surprising level of accuracy in our model and future inclusion of more diverse data from cell cultures is likely to improve our model considerably.
Proteins in the eIF-4A family form part of the ribosomal machinery and are involved in binding and unwinding mRNA for translation, while some eIF-5A isoform family members have more diverse functions in cell division and related processes [ 30].
