As shown in table 2, Sam50/Tob55 contains the lowest number of possible cladistic markers, which most likely reflects its highly specialized function The higher number of cladistic markers observed for Tom40 resulted from more divergent function involving not only import but also metabolite transport as well as from the presence of isoforms.
Considering the lack of information regarding eIF3 structure and function in more divergent eukaryotes, the sequence analysis performed here can also help pinpoint conserved elements, in different subunits, so far overlooked but which might have relevant functional roles and are in need of a proper investigation.
The more divergent proteins include several with immunomodulatory functions, such as A238L, which varies in amino acid identity from 58.9% (Malawi Lil20/1) to 81.3% (Mkuzi) compared with Georgia 2007/1.
When ω > 1, gene function will be more divergent.
Not surprisingly, the four S. cerevisiae Ssa Hsp70s supported growth reasonably well, although the somewhat more divergent inducible Ssa3p and Ssa4p did not function as well as Ssa1p and Ssa2p.
Another, more divergent grouping of opsins are the photoisomerases, which function to bind all- trans retinoids and photoisomerize them to their 11- cis-forms.
Barr [ 3], in his evaluation of the social welfare states, points out that the structures of medical care organizations are internationally more divergent than those providing benefits, the other major function of the welfare state.
This is consistent with sequence analysis showing that, as a ribosomal protein, the first two-thirds of LAMR are highly conserved, whereas the C terminus is more divergent among higher organisms (most likely to acquire extracellular functions).
Projections of these two VSN populations remain segregated at the level of the accessory olfactory bulb (AOB), and overlap only in more central brain areas, supporting both the possibility of divergent functions as well as synergy between the two subsystems.
