Exact(4)
However, greater percent identity of the genes within this class suggests they evolved more recently than the more divergent Class A genes (fig. 2).
While multiple gene conversion events can also result in the misleading appearance of a species-specific expansion, the more divergent Class A Mups form a distinct clade from the rat Mups and we find no evidence of gene conversion events in this class.
Our results show that the mouse Mup gene cluster is composed of two subgroups: an older, more divergent class of genes and pseudogenes, and a second class with high sequence identity formed by recent sequential duplications of a single gene/pseudogene pair.
More divergent class II sequences were named SppuDBB, DCB, and DDB.
Similar(56)
Gene mll2387 belongs to class A, while mll2386 is more divergent and considered a class B sHSP.
The more divergent NKG2D, which binds MHC class I chain-related genes, MICA/B, and the UL16 binding proteins (ULBPs) in human [ 46], was also detected.
sHSP can be divided into two classes in terms of sequence: class A includes sHSP similar to E. coli IbpAB, while sHSP grouped in class B are more divergent in terms of sequence.
Finally, the promoter elements of the MHC un-linked class I genes are identifiable and highly similar in sequence identity to the promoter regions of class Ia genes in the opossum (Modo-UA) and eutherian mammals, while the promoters of the putative class Ib genes are more divergent (see detailed analysis below).
Additionally, the TEP1s and TEP1r allelic classes are known to be more divergent in some regions of the gene than others [ 23, 25].
Specifically, it was observed that genes in the signal transduction pathways have strict 1 1 1 orthologues, and their sequences are more divergent than orthologous trios from the other three classes.
In addition to their classical DAA sequences, Atlantic salmon and rainbow trout contain three other class II alpha sequences, which are much more divergent than the different sequences identified in zebrafish or fathead minnow.
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