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Given the conservation of expression between mouse and human organs, we asked if this is also true for more distant vertebrates.
The data set includes also more distant vertebrates Gallus gallus and Xenopus tropicalis to investigate whether there are tDNAs with very stable genomic locations.
Particularly relevant in this context is the work by Prabhakar et al. showing that non-coding regions conserved between primates, but lacking visible conservation in more distant vertebrates are active transcriptional regulators [ 25].
The conservation of distance between pairs of UCEs [ 1] is also found between evolutionarily more distant vertebrates, but the distributions of RDD values show a persistent nature of distinct two-peak profiles in all mammal – non-mammal comparisons, with one peak close to zero, and another at a more negative value [ 5].
Overall, we believe that our method is a robust and rapid approach for identifying human microsatellites conserved in mammals, especially in eutherians, but will suffer from badly aligned sequences when applied to more distant vertebrates (supplementary fig. S9, Supplementary Material online).
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Evolutionarily more distant vertebrate p53 proteins (Xlp53 and Drp53) showed a very similar specificity profile but somewhat higher specificity.
To investigate this possibility we looked for TFRs in more distant vertebrate lineages whose genomes have since been sequenced, i.e., fish and frog.
The more distant vertebrate lineages such as the jawless hagfish and lampreys possess only small islet organs containing insulin- and somatostatin-producing endocrine cells and these islets lack any glucagon-producing cells or exocrine function [ 2– 4].
Evolutionarily more distant vertebrate proteins (zebrafish Drp53 and frog Xlp53) exhibited a selectivity pattern very similar to the mammalian proteins but showed higher bit score values of 10.8 and 12.8.
Table 3 extends our previous analysis of mammals and vertebrates to include more distant members of the animal kingdom.
So we will take a different route here, starting with our own familiar branch, the vertebrates, and working backwards to more distant and unfamiliar relatives, attempting to describe events in evolutionary history that are well constrained, through to those that are not so well constrained.
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more distant levels
more distant horizons
more distant synthesizers
more distant applications
more distant relatives
more 'modern vertebrates
more distant neighbours
more divergent vertebrates
more distinct vertebrates
more distant areas
more distant parallels
more distant environments
more distant memories
more distant concepts
more distant sources
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