Instead, Wroblewski and his team combed public records and interrogated Bala's more distant associates, constructing a profile of the suspect, which they then compared with the profile of Chris in the novel.
Profile profile comparison is more sensitive (Panchenko, 2003) than profile-sequence comparison, thus more distant relations could be detected during profile clustering.
This notion is supported by the observation that ESBL-EC had more diverse pulsed field patterns and resistance gene profiles, consistent with more distant epidemiological linkage between isolates.
Workers of the Argentine ant Linepithema humile showed elevated aggression against conspecific workers that were chemically more distant, while conspecific workers with similar profiles were treated amicably [ 49].
Preliminary results indicated that this is a better approach than a standard BLAST search [ 16] on individual sequences, which may not return enough sequences due to server-side limitations, and also better than PSI-BLAST [ 17] because PSI-BLAST finds more distant relatives through iterative queries against profiles determined by conserved regions.
This suggests that the imprinted status of the locus could be related to a differential methylation profile of other more distant CpG islands, or to other epigenetic mechanisms of regulation of monoallelic expression.
He lowered his profile, often driving to more distant communities to run routine errands.
Genome wide expression profiles of C. burnetii from in vitro cell culture were more similar to those seen for in vivo conditions, while gene expression profiles of cell-free culture were more distant to in vivo.
Briefly, the software performs an iterative sequence search of the user-supplied protein sequence using position-specific iterated BLAST (PSI-BLAST) creating statistical profiles and using them to gather progressively more distant homologs in each round.
Due to linear scale used, adjacent metagene profiles in the grid are more similar than more distant ones and the most distant metagenes roughly cover the whole range of input data.
