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For more distant markers, the |D'| was lower as the MAF threshold increased.
Because the recombination rates between these more distant markers and the QTL are higher, they will loose their predictive value more quickly compared to markers near the QTL.
As a consequence, two markers that are very close may show a low level of LD, whereas more distant markers may show a higher level of LD than expected.
When individuals in the reference population are more related, they will share longer stretches of chromosomes surrounding the QTL, allowing more distant markers to explain QTL variation within the reference population.
Squared correlations from actual or simulated genotypes were about equal on average for markers separated by 10 to 3000 kb, but actual genotypes had a wider range of values with more very high or low squared correlations that continued across more distant markers.
Similar(54)
For the more distant marker rs12970134 and for the obesity effect haplotype [A; G] of Haplo 3, the effect was slightly reduced in comparison to the model of not removing the mutation carriers.
The more distant a marker is from the 45° line in the figure, the larger the imbalance in the two categories of emissions.
F-value decreased as the SSR markers became more distant from RM164, showing 101.7 for RM18614, which was around 40 Kbp upstream of RM164, and 49.2 for RM3315, which was about 1.5 Mbp downstream of RM164 (Table 4; ANOVA).
If two adjacent markers are more distant from each other than the size of the BAC clones (∼80 Kbp), they will segregate independently.
Since SNPs were not selected based on location of previous colon cancer susceptibility loci, some markers were more distant, resulting in reduced power to replicate previous results.
The structure of the reference population is expected to have an effect on the persistence of accuracies because it affects how well the genetic variance of QTL can be assigned to markers near the QTL as opposed to markers that are more distant.
Related(20)
more distant parameters
more distant landmarks
more distal markers
more permanent markers
more distant particles
more common markers
more distant settlements
more important markers
more distant zones
more distant populations
more distant quarters
more distant levels
more distant horizons
more proximal markers
more distant applications
more distant synthesizers
more direct markers
more distant relatives
more distant neighbours
more meaningful markers
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