Sentence examples for more distant genes from inspiring English sources

As yet, there is no evidence that the risk alleles influence FTO expression and the variants could conceivably influence adiposity through effects on more distant genes.

More distant genes in this region include several Toll like receptors (TLR1,6,10) and PTTG2 (a gene belonging to the securin family) that plays an important role in cell division and survival[19], [20].

Our in situ hybridisation and chromosome conformation capture data support the hypothesis that enhancer 5F7 contributes to the expression pattern of OLIG genes in the posterior diencephalon but could also be regulating other more distant genes.

Since we cannot rule out the possibility that HSF may be acting on more distant genes, we extended this analysis to identify all genes within a 2500 bp window centered on the peak of each HSF-bound segment and calculated the distance from peak to TSS for each of these genes.

Direct neighbours are more often co-expressed than are more distant genes.

The correlation with more distant genes was not significant (Table 1).

It has also been suggested that a more distant gene on 9p21, MTAP (Fig. 1), could mediate disease associations [3], [4].

As both genes face each other "head to head" the available P-elements located 5' of each gene may also affect expression of the other more distant gene if enhancer elements are shared (Figure S3a).

Second, while rs3864180 is found within an intron of GPC5, this does not definitively prove the involvement of GPC5 in SCD risk, since it is possible for the functional variant to act upon a more distant gene [31].

In contrast with these other local fusion types and more distant gene fusions, which generally have a DNA-based mechanism, readthrough fusions have a plausible RNA-based mechanism.

In addition, in a probabilistic analysis, spliced alignments across TIC gene pairs should provide higher odds ratios than alignments across more distant gene fusions, because the short distance of TIC gene pairs in the genome limits the universe of possible alternative hypotheses.