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This shifting is propagated to successively more distant cells.
More distant cells exhibited development of Thy-1+ extending processes (left black arrowhead), suggesting early stages of neuronal differentiation.
The increase in Ca2+ can activate Panx1 channels and subsequent release of ATP provides a new source for extracellular ATP to reach more distant cells [ 86].
Depending on the rate of recycling of endosomes to fuse with the plasma membrane and release their contents extracellularly, it may also lead to less drug being available extracellularly for penetration to more distant cells.
As a consequence they are targeted into the secretory pathway and once extra-cellular play a –autocrine, paracrine, or endocrine- signaling role for example by activating G-protein coupled receptors of neighboring or more distant cells.
Furthermore, in contrast to senescent cell types that have surface IL-1α that is likely to only affect neighboring cells, IL-1α secreted from senescent VSMCs might stimulate more distant cells.
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From loop 10, cells 2 and 4 experience blocking and start to decrease their power, trying to send users to cell 3, which is the more distant cell.
FMM and BH are very similar methods; both use particle-particle (PP) interactions for nearby particles and a multipole expansion of the mass within a more distant cell to approximate the force (PC-interactions).
In the absence of lineage-tracing studies, however, a contribution from different or more distant cell types, perhaps entering through the capillaries, cannot be ruled out.
The major finding is that isolated mammalian synapses, severed from their adjoining axons and dendritic shafts and disconnected from the more distant cell bodies, are not only competent to carry out the functions associated with basic neurotransmission but can also robustly emulate core adaptations associated with glutamatergic synaptic plasticity.
Immunohistochemical analysis revealed that tumor cells located less than 100 μM from a capillary in brain metastasis are viable, whereas more distant tumor cells undergo apoptosis [ 59].
More suggestions(15)
more distant particles
more distant relatives
more distant neighbours
more positive cells
more distant settlements
more distant zones
more red cells
more distant populations
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more distant synthesizers
more distant applications
more fat cells
more immune cells
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