Moreover, this study determined events within one year from exposure, which may strengthen the association as compared to choosing a more distal time-point.
For the profiles depicting the effect of CPA and termination factors at the TES, only the adjacent region was considered that extended to TES+7 kb in order to allow inclusion of more genes, while at the same time capturing more distal effects.
This process took advantage of the oiled-plate tether and the known 3D geometry of the legs – specifically, that the body (and therefore the thorax-coxa, or ThC, joint) does not change position during the experiment, that lengths of the leg segments should be fairly constant in time, and that more distal points can move more quickly than more proximal points.
There was a statistically significant difference in translation in the y-direction (proximal-distal) between the groups at 6 months and 1 year, with the TM group showing more distal migration at both follow-up times (p < 0.001).
Increased kinematic variability over time was observed in the shoulder joint; however, decreased kinematic variability over time was seen in the more distal part of the upper limb.
Shorter exposure to doxycycline resulted in a milder phenotype, as embryos exposed to doxycycline for shorter time periods developed some of the more distal cartilage rings.
Observed microseismicity displayed distinct linear clustering and increased in distance from the injection well over time, presenting challenges for location accuracy of more distal events.
SIV entry is a very rapid process, as infection is established in the lamina propria, in lymphoid aggregates and in more distal sites at least at four hours pi, the earliest time point assessed.
Locating the simulated source in a more distal area approximately 1000 m from the supply well increases the time for contaminant breakthrough to about 20 years.
At the same time, comparisons between ACy12 (more proximal) and ACy14 (more distal) suggest that any such gradient is gradual and that retrosplenial inputs can arise from across the transverse width of the subiculum (see also Kobayashi and Amaral, 2003).
It is possible that as distance between assessment time points increases and measurement of variables becomes more distal, other factors attenuate direct relationships between family dysfunction and poor metabolic control.
