Some also use the metabolic intermediates to modulate more distal processes n their scheme of stimulus-response coupling.
We suggest that incorporating more distal processes into analyses and designs of interventions will result in more sustainable interventions.
Presumably, the channels are located on the more distal processes that are shorn off during the isolation procedure, an interpretation consistent with immunocytochemical findings that the HCN channel protein in the DCN is concentrated in the neuropil (Notomi & Shigemoto, 2004).
Nonetheless, since GRK2 inhibition appears only partially to prevent ETAR desensitization, it is possible that other mechanisms are involved, perhaps involving more distal regulatory processes such as β-arrestin binding, receptor internalization and/or receptor down-regulation.
Attention to these proximate and more distal users in the valuation process is a complex and constitutive feature of the work of health technology transfer.
It has been hypothesized that intention to quit is a proximal precursor of turnover and that work-related factors may represent more distal causes in the withdrawal process [ 12].
Thus, proximal and simple cues that instigate behavior (e.g., sexual arousal) continue to be processed, whereas more distal and complex cues that would ordinarily inhibit behavior (e.g., the possibility of contracting an STI or an unplanned pregnancy) are no longer adequately processed.
Moreover, when comparing transcript expression in different immune cells (T lymphocytes, B cells, monocytes) before and after stimulation, a decrease of the expression of longer isoforms, which are processed at more distal PASs, has been reported to be associated with higher proliferation states (Sandberg et al, 2008).
Values clarification methods may improve decision-making processes and potentially more distal outcomes.
We focus on water-related diseases (such as waterborne and vector-borne) and their more distal causes, which involve both social and ecologic processes.
This model is composed of proximal confined units where channelization processes, amalgamation and bypass dominate, to more distal and less confined units where compensation, constructive structures and high deposition rates control sedimentary architectures.
