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Alginate encapsulation may have reduced oxygenation to the progress zone of the developing limb bud resulting in lack of development of the more distal elements.
This process is dependent on an intact AER, the removal of which leads to truncations of the skeleton with progressively more distal elements forming the longer the AER remains in place [40]).
Attenuation of inhibition can also be seen in the proximity of the more distal elements to the dorsal and ventral surfaces as the limb bud tapers towards its tip, and to the apical boundary, as the potency of the AER wanes [10].
The more distal elements are evidenced only by their spines.
More importantly, three or more distal elements form the functional finger of the subchela in thylacocephalans as well as in remipedes.
Rotation of the leg bones can have a major effect on the orientation of some more distal elements of the limb and, thus, greatly influence gait dynamics.
Similar(51)
Unlike the joint loss found with RNAi targeting Notch signaling, which affected all tarsomeres equally, proximal tarsal elements (t1 t2) were far more sensitive to odd-paralog depletion than were more distal tarsal elements.
Homotypic clusters are prevalent in both bacterial and eukaryotic genomes, and are present in both promoters as well as more distal enhancer/silencer elements.
Evidence for posterior prevalence in the adult is apparent; Hoxa13 is not expressed in the femur samples whilst Hoxa13 is expressed in tibial and ulnar bones which are the more distal skeletal elements.
In agreement with previous studies, our results indicated that more distal regulatory elements contribute to diversity in AVPR1A and Avpr1a expression levels and distribution patterns.
Chromatin looping is a consequence of the association of proteins bound to two or more distal regulatory elements (see, for example, [ 50, 51, 53- 55] and references therein).
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