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Exact(6)
The refolded S228P protein had a much higher light scattering intensity than the WT protein (Fig. 4D), implying that the refolded S228P either had more disordered regions or had a larger oligomeric size.
In a detailed comparison within the IVV core data set, we observed more disordered regions (residues) in class 2 IRs than in class 1 IRs (p<2.0e-06 p<2.0e-06
As a consequence, there is a wide variation in protein and side chain conformation in the weaker and more disordered regions of the map; this situation can change with improved order in the crystals and resolution of the data.
Proteins involved in non-obligate interactions tend to have more disordered regions and short linear eukaryotic motifs than obligate interactors.
The amino acid compositional trends in the environment of phosphorylation sites also suggest a preference for more disordered regions of proteins.
In their recent study on protein-protein interactions, Ekman and co-workers noted that hub proteins (those with a large number of interacting partners) are more often multi-domain proteins and contain more disordered regions compared to non-hubs.
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The G-band positions of the three category 3 particles are located in a more disordered region than that of the chondritic primitive IOM.
Eukaryotic proteins apparently have more intrinsic disordered regions than those of bacteria or archaea [ 2], suggesting also more important functions such as being involved in signaling and regulation of gene expression [ 3].
The half-life of proteins with more internal disordered regions tends to be 7 min shorter (median) than that of their paralogs (Table S6A), which again can be a considerable amount of time considering the doubling time of yeast.
In the present work, we propose a model for hArc as a protein containing two domains with a large content of helical structure on either side of a central, more disordered linker region.
Limited proteolysis assays and MS analysis indicate that hArc has two major domains on either side of a central more disordered linker region, consistent with in silico structure predictions.
More suggestions(14)
more affordable regions
more disordered aggregates
more specific regions
more productive regions
more disordered arrays
more intergenic regions
more disordered mesostructures
more illustrious regions
more racist regions
more souther regions
more clustered regions
more disordered structures
more dense regions
expected disordered regions
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