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Choice of outcomes is guided by a Health Technology Assessment commissioned systematic review recommending that HbA1c (glycaemic control measure) is not the appropriate primary outcome on which to assess benefits of an intervention designed to more directly effect behaviour/self-management [ 39].
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Since it is the aim of this study to determine where those who are more directly effected are geographically, the analysis must account for these spikes occurring in any or all of our cities.
By contrast, our study investigated more directly the effect of fezf2 upregulation and downregulation on Wnt/β-catenin activity using a number of assays, which all consistently showed that fezf2 increased the activity of Wnt/β-catenin signalling.
To test more directly the effects of Hox4 misexpression on segmentation, we used in ovo electroporation of chick embryos at the 7- to 12-somite stage (HH stages 9-11), when rhombomere boundaries are forming (Vaage, 1969; Lumsden, 1990).
Targeting another factor downstream of HER2 that more directly mediates effects specific and essential to the development of AI resistance may be as effective as targeting HER2 itself, while not having the same level of risk of producing second-line acquired resistance.
We used this statistic as it more directly describes the effect of a test result (in this case GRG status) on the odds of disease [59].
However, about the main limitations of the present study, future research may explore more directly the intrinsic effect induced by facial expression of emotion taking into account also gender effect.
The sense of crisis in contemporary art and letters has often been translated to the realm of the individual (witness the current appetite for personal memoirs like "Angela's Ashes"), and responses often aim more directly at emotional effect.
To look more directly for an effect of CLIC4 on TGFβ signaling following acute kidney injury, we assessed phosphorylation of the SMAD pathway.
To more directly explore the effect of ShcY317F on TRK-T3 induced transformation we constructed NIH3T3 cell lines expressing exogenous ShcWT and ShcY317F proteins.
To more directly compare the effect of blocking TRPC3 between lobule III and X, we recorded PC activity during wash-in of the blockers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com