Clearly, enhanced ERα and PR expression would sensitise the premalignant epithelium to the proliferative effects of their cognate ligands, but it remains to be determined whether oestradiol and progesterone continue to drive proliferation by the indirect mechanisms that exist in the normal epithelium or whether an alternative, more direct, pathway has arisen during malignant transformation.
Instead of running agarose gels to check the size distributions, a more direct way is to use several batches in a transformation experiment and retain the one that gives the highest transformation efficiency regardless of its size distribution.
The custom protocol includes more comfortable/stable positioning and adapted cortical segmentation and direct transformation analysis methods.
This system will not only allow for the monitoring of MaSC activity in normal physiologically relevant processes but will also permit more direct evaluation of the susceptibility of MaSCs to oncogenic transformation and the regulation of their growth throughout tumorigenesis.
God has given us senses and the ability to comprehend microevolution without the necessity of "seeing" a direct transformation of one species into one or more different species.
Genetic transformation or genome editing may be a more direct means to obtain certain traits, but such approaches are rarely economically viable for ornamental plants.
Among the compounds tested, carbamazepine exhibited the lowest tendency for direct transformation by UV light (<30% removal for all matrices), while more photoreactive compounds, such as sulfamethoxazole, propranolol, and atrazine, displayed higher removals (55 99%).
Or, even more direct, NBC Universal was afraid that going from the analog era to the digital era would mean a transformation of revenue from "dollars into pennies".
Kinetically and microstructurally it is more direct, with an effective pathway of TiO2 → Ti2O3 → TiO → Ti metal at an inward-moving transformation front.
More direct evidence was presented by Kolligs et al (2000), who demonstrated that overexpression of wild-type plakoglobin elicits neoplastic transformation in a rat kidney epithelial cell line.
