Sentence examples for more direct mutation from inspiring English sources

Each mutant gene has a higher probability (by several orders of magnitude) to get one more direct mutation than to reverse.

More direct measurements of mutation rates are now possible using whole-genome sequences of isolates sampled from evolution experiments.

To increase the precision of extinction time estimates it would be desirable to have more direct empirical estimates of mutation rates and effects in the Amazon molly.

More direct evidence against a mutation- or dinucleotide-driven explanation is found in the observation that the majority of GC boxes in the target region originates de novo from nonfunctional DNA and only rarely arises from GA boxes.

Other CdLS-related HDAC8 mutations exert a more direct effect on catalysis, such as the H180R mutation that removes a protein ligand to the catalytically obligatory Zn2+ ion.

Although the Hb variant carriers reported herein are phenotypically silent, this study provides a much safer approach, since the comparison is more direct and performed between identical mutations in the α-globin genes, yielding identical globin chains.

Alternatively, pathway activation without direct mutation may portend a more plastic target, less addicted to the pathway's output and thus more able to evade inhibition.

The identification of dZIP13 as the iron exporter for the secretory compartments suggests a more direct interpretation of SCD-EDS: ZIP13 mutations impair iron transport to ER/Golgi, significantly attenuating the activities of iron-requiring enzymes such as lysyl hydroxylase, leading to defective collagen synthesis and accumulation in the secretory pathway.

Mutations in microsatellites provide an alternative and more direct avenue to determine susceptibility to DNA damage.

However, more direct functional associations of APOBEC family member(s) proteins with clustered mutations have to be carrying out.

This suggests that if ST7 is the key TSG at 7q31, it is more likely to be inactivated by epigenetic mechanisms or haplo-insufficiency than by direct mutation.