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Suggesting a more direct functional link between the actin cytoskeleton and G-proteins, Gβγ subunits were found to be physically associated with actin filaments in several cell lines [40].
However, more direct functional associations of APOBEC family member(s) proteins with clustered mutations have to be carrying out.
The intratumoral T-cell infiltrates may be associated with a more direct functional effect on tumor cells.
This, however, was mainly inferred from the co-immunoprecipitation of overexpressed AID and Gadd45 with TDG and therefore needs to be corroborated by more direct functional evidence.
These studies also highlight a need for more direct functional analyses of the roles of miRNAs in regulating pathways relevant to tumour pathogenesis.
Recent work has shown on a small level that resequencing of candidate regions from GWASs can often uncover rarer variants with higher effects and more direct functional consequences in common diseases [ 2].
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These results adjust our understanding of human agriculture history and will provide the foundation for more directed functional studies and a better understanding of genetic diversity in date palm.
In the present study, however, the most prominent ISI for inhibiting the N20 response in the left S1 was much shorter and ranged between 20 and 25 ms, suggesting the operation of a more direct S1-S1 funconnectionnneconnection
Differential species-specific induction of antibody responses may allow for more direct analysis of functional versus non-functional B-cell epitopes.
As protein levels and function depend not only on translation but also on post-translational modifications, functional proteomic profiling may theoretically yield more direct answers to functional and pharmacological questions than transcriptional profiling alone.
To allow more direct comparisons with functional assays, we compared IP3 and AdA binding to the isolated IBC and NT in CLM.
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