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At the cellular level, ABCG5 appeared to be apically expressed, whereas ABCG8 had a more diffuse expression pattern.
In neoplastic tissue, this normal staining pattern was lost and more diffuse expression seen.
However, s6T assumed a more diffuse expression that did not exceed 5% of the tumour area in all cases.
HK-2 and PK-M2 showed a weaker and more diffuse expression pattern compared to the aforementioned antigens (Additional file 3: Figure S2).
Nevertheless, HIF αs and LDH-5 are additionally regulated by oncogenes and cytokines, which may account for their more diffuse expression than CA9.
In the contrary, DDLPS and PLPS subtypes, which are classified as being more immature LPSs, display stronger and more diffuse expression of MSC markers (HGF) than WDLPS and MLPS.
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Immunoexpression of neuroendocrine markers is more limited (diffuse expression of Syn, faint or focal staining for CgA) [ 1].
Smaller minimal |r| values indicate more "diffuse" co-expression modules with weaker co-expression relationships, and larger minimal |r| values indicate "tighter" co-expression modules with stronger co-expression relationships.
These alterations tended to take the form of more diffuse β-gal expression in specific cell layers (e.g. in the olfactory bulb), and decreased segregation between identified laminae (e.g in the piriform cortex).
The high-expression group (score 3+ and 4+) showed more diffuse Ln5- γ2 expression within tumours, while the low expression group (score 1+ and 2+) showed focal Ln5- γ2 expression at the periphery of tumour nests or only at the invasion front.
Whereas both Notch-1a and deltaA domains are present in all proliferative zones of the brain, only the more diffuse and scattered deltaA expression appears to extend additionally into the adjacent postmitotic gray matter.
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