Moreover, in contrast to the very slight red fluorescence in DOX-MWCNTs-PEG, DOX-MWCNTs-PEG-TAT exhibited much stronger red fluorescence signals inside MG63 and HUVEC cells and displayed a more diffuse distribution, indicating that the TAT conjugated nanotubes were taken up more efficiently into MG63 and HUVEC cells.
Differentiating CT findings from sarcoidosis are the preservation of the architecture of the secondary pulmonary lobule, the more diffuse distribution if it is secondary to extrapulmonary cancer or the confinement to one lobe or lung if it is secondary to lung cancer and the less common incidence of mediastinal lymphadenopathy [6].
The Kuiper belt is quite thick, with the main concentration extending as much as ten degrees outside the ecliptic plane and a more diffuse distribution of objects extending several times farther.
In contrast, the distribution pattern of colocalized Rhod-2 and Mitotracker™ observed in control cells revealed spots of less intensity characterized by a more diffuse distribution (Figure 4E).
Disruption of the actin cytoskeleton using latrunculin A, a membrane permeable agent that binds specifically to monomeric G-actin and disrupts filamentous actin in cells [34], [35], also resulted in a more diffuse distribution of TbMyo1 (Fig. 4B).
The correlation of 111In with endogenous CAIX improves over time and the wider spacing between the binned 111In data points is indicative of a more diffuse distribution of radioactivity within the tumor section.
Moreover, the increased expression of collagen V a collagen type that has been shown to accumulate in malignant disease [40] and the more diffuse distribution of Tenascin C an ECM protein that is overexpressed in pancreatic cancer [41] and of αSMA in AIPC compared to CP may account for the radiological and macroscopic tumor-like appearance of AIPC.
R133C-GFP and T158M-GFP, however, showed a more diffuse distribution throughout the nucleoplasm coupled with reduced heterochromatic localization.
6 One might believe that a more diffuse distribution of the product into the dermis, achieved by the monophasic gels, may lead to a more even therapeutic effect.
Both FLAG-Rab26WT (C ) and QL (D ) co-localize with a subset of synaptotagmin positive puncta (Syt-I), whereas FLAG-Rab26TN (E ) exhibited a more diffuse distribution.
