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Probably, a more specific statement will be needed in order to determine what "important adverse (or unexpected) effects of an intervention" mean for the statement: whether it be statistical significance (which is influenced by the statistical power of the RCTs to detect harm), or clinical importance (which entails a more difficult definition).
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Breakthroughs are, by definition, more difficult than routine innovations.
As such, teachers who left due to professional isolation and lack of strong relationships with other foreign language teachers would have been, by definition, more difficult to locate.
On the other hand, the target power is enhanced, also emphasizing the received electromagnetic diffraction produced in the unseen side of the ship, what makes the ship detection and shape definition more difficult.
Classifying food items into 'healthy'/'unhealthy' proved to be more difficult as no single definition of 'healthy' and 'unhealthy' foods exists.
In our view, the clinical presentation of patients with the NLRP3 E311K mutation may indeed expand the recognized spectrum of MWS features, which makes it even more difficult to give a definition of 'usual'usual
Generic definitions are more difficult to operationalize, and they trade specificity for generalizability; disaggregated definitions recognize that quality has different essential components, each providing only a partial picture of quality, but together the components create a more specific description of quality for particular aspects of health care.
Species definitions, although notoriously problematic even for macroorganisms, are even more difficult in microbes, and operational definitions based on similarities in DNA sequences must be used instead (as already discussed).
After that, however, the definition becomes more difficult.
Mr. Schoen added: "If this all went away, I think people would start focusing to a much greater degree on 'Who's John Kerry,' which is by definition a more difficult question to handle".
Twelve-tone or atonal music is more difficult to memorise because, by definition, it lacks the structure of tonal music – there's no way to predict what will come next, so every note has to be memorised by rote.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com