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Firstly, Lhx2 interferes with conversion of primitive ectoderm to more differentiated tissues.
In contrast, slow growing but more differentiated tissues such as skeletal muscle, adipocytes, spinal cord, brain, and basal stromal tissues near epithelial cells exhibited no or weak immune reactivity to APC7.
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It has been proposed that CSCs may arise through mutations accrued in normal tissue stem cells or more differentiated tissue progenitor cells [ 31].
All these lines showed increased tumorigenicity and/or growth rate, together with a change towards a more differentiated tissue morphology, when co-injected with matrigel into nude mice.
Transitions into more differentiated fatty tissue were found as well as areas with osteoblastic/osteosarcomatous (4B) and fibrosarcomatous appearance (4C).
The more complicated the species, the more functions and specifically differentiated tissues, the more complicated the wound healing process.
Therefore, if a woman has a full-term pregnancy and has not already had a prior initiation event, then the pregnancy would be expected to leave the breast tissue more differentiated and less susceptible to carcinogenic influences in the long term.
In contrast, there was weak or no p53 staining in the more differentiated cell compartments of these tissues, such as IGL of the adult cerebellum, villi of small intestines and differentiated cells in the tongue epithelium.
Furthermore, at least two lines of evidence suggest that stem cell-based tissue-replacement therapies might be hindered in the elderly, because all cells along the developmental lineage (e.g., stem cells, more differentiated progenitor cells or even tissues containing a pool of precursors) might rapidly 'age' and fail to contribute to organ repair when introduced into the old organism in vivo.
Those produced by tumour tissue transplants were more differentiated and were composed of spindle shaped cells with abundant collagen fibre formation.
Therefore, despite their general neoorganogenesis potential, the ability of hESCs, and the more differentiated myogenic ASCs to contribute to tissue repair in the old will be greatly restricted due to the conserved inhibitory influence of aged differentiated niches.
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