In this system, FGF2 was both essential and sufficient for the formation of more differentiated structures, the lentoid bodies (Yang et al. 2010).
The more differentiated structures being apparent after treatment with 17β-oestradiol in the original 3366 tumour were not induced in the resistant line.
Resveratrol-exposed female rats displayed more differentiated lobular structures and decreased proliferation in the mammary terminal ductal structures, making them less vulnerable to damage by carcinogens (Whitsett et al. 2006).
More differentiated lobular structures have been found to originate tumors whose malignancy is inversely related to the degree of differentiation of the parent structure; that is, Lob 2 originate lobular carcinomas in situ; Lob 3 give rise to benign breast lesions, such as hyperplastic lobules, cysts, fibroadenomas, and adenomas; and Lob 4 originate lactating adenomas [ 18].
Although lobular breast carcinoma and ductal breast carcinoma of comedo type differ in many respects histologically, both lack formation of more differentiated mammary gland structures such as tubules.
However, after HBO treatment a majority of the cases appeared to have a more differentiated morphology, with glandular structures and less marked cellular atypia as well as areas of cell death (n = 5) (Fig. 1C).
We conclude that DES, genistein, and o,p'-DDT given to pubertal rats act as morphogens; i.e., they increase cell proliferation, which promotes maturation of the undifferentiated terminal end buds to more differentiated lobular terminal ductal structures.
Full-term pregnancy induces a change in the breast's lobular structure to more differentiated lobules [ 25].
Compared to existing implementation theories, the paper offers a more differentiated way of describing and structuring the implementation processes that contemporary EU-directives are producing in a world coloured by multi-actor, multi-level and multi-sector governance.
It is especially important in IUGR pregnancies, where vasculature structure is much more differentiated due to the presence of villous infarcts [ 5, 14, 15].
