Sentence examples for more differentiated state from inspiring English sources

However, in certain cases, differentiation-inducing agents can reactivate a tumour cell's differentiation programme and bypass this defective growth regulation, forcing cells into a more differentiated state that has a more favourable clinical prognosis.

Equine tenocytes retained a more differentiated state when cultured as scaffold-free microtissue spheroids in low serum-containing medium supplemented with l-ascorbic acid 2-phosphate, insulin and transforming growth factor (TGF -β1.

Human ES and iPS cells seem to be at a slightly more differentiated state than their mouse counterparts, which makes it more difficult to grow certain types of cells from them.

However, these tumors also contained well-organized glandular bodies suggestive of a more differentiated state (Figure 7B, top right panel).

These cells grow rapidly at 33°C (permissive), but adopt a more differentiated state at 39°C (non-permissive).

By contrast, increased dosage of Δ40p53 caused an extension of pluripotency and prevented progression to a more differentiated state.

On the contrary, wild-type cartilages, which contain a mixture of cells in progressively more differentiated states, some of which already lost cell-cell contacts, expressed significantly lower levels of β-catenin and cadherins.

In the normal mammary gland as well as in the hematopoietic systems, the majority of stem cells are dormant and cells within the more differentiated states should have no possibilities to turn back into the parental stem cell state.

We showed that as cells advance from the embryonic to more differentiated states DSB repair occurred with faster kinetics and a dependence on ATR and HRR to a dependence on ATM for NHEJ [ 5].

PC1 seems to represent a transition of ES cells from a pluripotent state to more differentiated states because it is associated with a decreased expression of ES cell specific genes (e.g., Nanog, Zfp42, Nr0b1, Tcl1, Dppa3, Klf4, Jarid2), and increased expression of genes related to differentiation (e.g., Esx1, Gata2, Gata6, H19, Hoxa1, Msx2, Plat, keratins).

The results of the study support the notion that sequential activation of these two modifications specifies the transition from the "stem-like" neural precursor state to a more differentiated cellular state.