Sentence examples for more differentiated progeny from inspiring English sources
Such a model comprising stem/progenitor cells and field cancerization could account for phenotypic heterogeneity within individual mammary tumors, since tumors would be composed of tumor stem/progenitor cells as well as other more differentiated progeny generated through aberrant differentiation.
Through asymmetric division and differentiation, these stem cells generate more differentiated progeny that lack self-renewal capacity.
These data reveal that Hh pathway activation is heterogeneous across the spectrum of MM tumor stem cells and their more differentiated progeny.
The identification of a tumor cell subset that is capable of self-renewal and, concurrently, generation into more differentiated progeny has engendered new perspectives toward selective targeting of tumors.
These findings suggest that unrepaired DSBs accumulate continuously in hematopoietic stem/progenitor cells (CD34+) and their more differentiated progeny (CD34−) during physiological aging.
In normal adult tissues, telomerase is most active in long-lived stem cells and progenitors, and then progressively decreases in more differentiated progeny [22] [24].
Pancreatic cancers contain a rare population of undifferentiated 'stem-like' cells that are highly tumourigenic and give rise to more differentiated progenies.
16 As CSCs and their more differentiated progenies share the same genetic background, we hypothesised that the apparent mechanistic differences that exist between CSCs and non-CSCs are related to a unique epigenetic signature.
Classical glioma CSCs (GSCs) regenerate both themselves and more differentiated tumor progeny [3], but GSC differentiation results in decreased tumorigenicity [4], [5], [6], [7], [8], [9].
In contrast, DCX, ASCL1 and OLIG2, genes normally expressed by more differentiated neuronal progeny as well as cell cycle regulators CDKN2A and NF1, were preferentially expressed in the less aggressive tumors expressing low levels of CD95 (Figure 1f).
This assay allows us to specifically analyse apoptosis induction within the CSC population and compare it directly to the more differentiated tumor progeny.
