Sentence examples for more differentiated progenitors from inspiring English sources

This indicates that estrogen reduces the pool of self-renewing stem cells, most likely by promoting their differentiation and simultaneously escalating the proliferation of more differentiated progenitors.

According to the prevalent dogma, quiescent HSCs would favor endosteal niches whereas more differentiated progenitors might be found in vascular niches [41].

Of note, Fz6 expression has been shown to be decreased on more differentiated progenitors [49], suggesting that Fz6 could transmit Wnt signals that favor sequestration of β-catenin to the membrane in HSCs while alternative receptors might be preferentially used in LMPPs which are rapidly cycling cells, presumably more loosely tied to the niche.

Recently, the presence of Sox2+/Sox9− of the mouse pituitary has been described and proposed to mark stem cells, localized both as an epithelial layer but also heavily intermingled with the differentiated cells [10], while more differentiated progenitors or transit-amplifying cells would become Sox2+/Sox9+.

Furthermore, HDAC3 deficiency in mice results in accumulation of immature MPPs at the expense of more differentiated progenitors 25.

The gene was recently revealed as a marker of haematopoietic stem cells distinguishing these cells from more differentiated progenitors [ 63].

Those cells, i.e., cancer stem cells, are derived either from transformed normal stem cells or more differentiated progenitor cells that have acquired the ability of self-renewal as a result of oncogenic mutation [3].

However, neurospheres are limited in that they contain a mixture of neural stem cells and more differentiated progenitor cells in a common extracellular matrix [26] [28].

In animals, stem cells have the ability to undergo an asymmetrical, self-renewing cell division, resulting in one stem cell and one more differentiated progenitor cell [ 2].

BTICs consist of a heterogeneous population of cells that include a small percentage of bCSCs as well as a range of less to more differentiated progenitor cells.

In an elegant study Purton et al. [ 19] have shown that loss of RARα1, but not RARα, results in reduced numbers of HSCs and increased numbers of more differentiated progenitor cells in the mutant mice.