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As larger and more differentiated populations were analysed the G1 peak of the cell cycle decreased whereas the G2/M and polyploid fractions increased (Fig. 1a,b).
In light of these findings, we hypothesised that the SCs in prostate cancer would be more resistant to irradiation than the more differentiated populations.
However, precision in the attribution of C. jejuni may be less than that of Salmonella, in which different animal and bird species appear to host more differentiated populations (3 ).
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Although it is currently unknown whether these cells can differentiate into NLCs, RA-NLCs are a more differentiated population.
Very few transcripts (5) were distinctively overexpressed in the more differentiated population (Sca-1Lo-only cluster).
For this experiment we predicted that the more differentiated population will increase early after injury and continuously decrease from day 7 to14 as the muscle reaches full regeneration.
Finally, Americans were heterogeneous at all distance bins, and this effect cannot be attributed to any single population: dropping the apparently more differentiated population, the Surui, still results in 14 significant tests in 19 distance bins.
This data demonstrates that FLT3/ITD evolves initially in the progenitor population as a heterozygous clone (that is, no CN-LOH13q), and subsequent events likely lead to the evolution of CN-LOH13q in the more differentiated population.
In order to confirm that the metabolic differences observed are indeed due to differences between CSCs and more differentiated cancer cells, we sorted CD24−/low cells within the sphere culture, supposed to be the less differentiated more stem-like cells, and compared them with a more differentiated population expressing higher CD24 levels.
1; PGHS-1 enzyme levels are higher in the more differentiated population of MEG-01 cells and 2; when MEG-01 cells are induced to differentiate upon addition of TPA, the levels of PGHS-1 enzyme increase only in the adherent cell populations that are destined to differentiate into platelet-like structures.
Regarding B. alpina ingroup populations, samples from topographically isolated mountains are expected to be genetically more differentiated than populations separated by less shallow elevations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com