The infectants became more differentiated than the parental cells as determined by a decrease in the synthesis of the embryo-specific alpha-fetoprotein in HepG2 and McA RH 7777 hepatoma cells and by an increase in melanin synthesis in mS cells.
From 78 % to 89 % of genes resulted under expressed (|logFC| ≥ 0.585 and p-value ≤ 0.05) with respect to the more aggressive and less differentiated parental cell line.
Gefitinib-resistant GLM-1R cells exhibited increased EGFR expression and more differentiated morphology as compared with parental GLM-1 cells.
ICCAP aims to measure quality of life as a result of parental stress and is more differentiated than SF-36, whereas the latter aims to measure general quality of life.
IFN- γ-transfected cells from both the cell lines displayed a more differentiated phenotype, that is presence of neurites, than their parental counterparts (data not shown), as observed following treatment with hr IFN- γ (Ponzoni et al, 1992).
In the normal mammary gland as well as in the hematopoietic systems, the majority of stem cells are dormant and cells within the more differentiated states should have no possibilities to turn back into the parental stem cell state.
Parental hiPSCs and five independent mutant clones were once more differentiated into BRN3A-positive neurons, to quantify resulting average neurite lengths.
CSCs can divide to yield a more differentiated cell and a daughter cell that maintains the same properties as the parental cell.
GLM-1R tumour xenografts in nude mice exhibited more differentiated histology with well-defined tubular structures and stronger membranous staining of EGFR than parental GLM-1 tumour, whereas HER2 expression remained unchanged between the two.
In contrast, the same level of arsenite will induce transformation in its isogenic, mature heterogeneous parental RWPE-1 cell line, but this takes 30 weeks, and the cells form much more differentiated tumors of epithelial origin with mature prostate qualities [ Achanzar et al. 2002; see Supplemental Material, Table 1 (doi:10.1289/ehp.0901059.S1)].
