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Cells in which heterogeneous Nanog expression was initially induced showed a more differentiated morphology and an enhanced expression of differentiation markers in comparison to cells maintained in 1 μg/ml doxycycline.
This cell line presented a more differentiated morphology, with bipolar extension of two processes (Figure 8A).
However, after HBO treatment a majority of the cases appeared to have a more differentiated morphology, with glandular structures and less marked cellular atypia as well as areas of cell death (n = 5) (Fig. 1C).
Gefitinib-resistant GLM-1R cells exhibited increased EGFR expression and more differentiated morphology as compared with parental GLM-1 cells.
An extended tumour latency period in excess of 3 weeks was observed in the resveratrol treatment groups, with the resultant tumours retaining a more differentiated morphology as compared with control animals [ 18, 39].
Class 1 (luminal) includes the MCF7 and SUM225 lines that were mainly CD24+ and exhibit a more differentiated morphology and luminal cytokeratin expression, which is consistent with their luminal-type classification [ 8, 21].
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Accordingly, in the BrdU/PSA-NCAM double stainings carried out at 5, 10, and 15 days post-injection survival times (Figure 1L O) the occurrence of bipolar double-labelled cells was more frequent at early survival times, whereas that of more differentiated morphologies (neuronal-like) was detectable at subsequent survival times (see Figure S2A).
All these lines showed increased tumorigenicity and/or growth rate, together with a change towards a more differentiated tissue morphology, when co-injected with matrigel into nude mice.
As a consequence of this, CD44+ cells specifically respond to an inhibitor of TGFβR, and acquire more differentiated epithelial cellular morphology and membrane localization of E-cadherin and β-catenin.
MET-depleted ARMS cells acquire the morphology of the more differentiated spindle-shaped ERMS cells.
The number of differential cells were counted according to differentiated morphology and expressed as a percentage of total cells.
More suggestions(15)
more extended morphology
more physiological morphology
more differentiated description
more vacuolated morphology
more mesenchymal morphology
more differentiated phenotype
more differentiated growth
more differentiated lavas
more uniform morphology
more elongated morphology
more differentiated suprabasal
more extreme morphology
more round morphology
more differentiated manner
more stellate morphology
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