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Consistent with the finding of proportionately fewer naïve T cells, Malawian adolescents have proportionately more memory (CD45RA-CD45RO+) T cells, and more differentiated memory T cells (CD28-CD45RO+) than UK adolescents.
When comparing CMV+ and CMV− individuals we found that the memory phenotype distribution of tuberculin-induced CD4 T-cells displaying degranulation, TNF-α and IFN-γ production was more skewed toward more differentiated memory compartments.
Differences between these populations in the proportions of naive, memory and/or more differentiated memory T cells, perhaps attributable to the more frequent natural exposure to various infectious agents in Africa, may be a factor contributing to the difference in the ability of Malawians to respond to BCG vaccination.
The reduction that we observe in the representation of naïve T lymphocytes with a concomitant increase in more differentiated memory T cells is similar to findings in elderly individuals [ 30], although it may have arisen by different mechanisms in the Malawian adolescents.
Similar(54)
Platelets bound preferentially to those subsets of CD4+ and CD8+ T cells that had a more differentiated phenotype (memory, memory/effector and TEM).
This decreased IL-2 production and increased lytic activity in the OKT3/IL-2 T cells suggests that the OKT3/IL-2 T cells are more differentiated toward effector memory cells, with increased direct tumor-controlling ability and decreased migration and proliferation potential.
This kind of variation was seen both in the resting naïve T cells as well as in the more differentiated effector and memory T cells [41].
Both splenic CD4+ and CD8+ T cell populations show a higher number of activated cells and splenic CD8+ T cells show a more differentiated cytotoxic CD27-CD45RA+ CD27-CD45RA+type.
Platelets can form conjugates with T cells and were preferentially seen in CD4+ and CD8+ T-cell subsets with more differentiated phenotypes [memory, memory/effector and terminal effector memory (TEM ].
This unique long-term improvement of immediate verbal memory of the pure CT points to the fact that at least the effects of the interventions on memory might need to be regarded in a more differentiated way.
CD4+ T cells tended to express more markers associated with being "central memory" (CCR7 and CD27) [33], [33]; CD8+ T cells appear to be more differentiated.
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